To identify putative metabolism-related genes perturbed by hyperthyroidism in the skeletal muscle and potentially modulated by Vit E, we analysed the expression of genes encoding glucose transporters (e.g., Slc2a1 and Slc2a4), genes involved in muscle lipid homeostasis and insulin signalling (e.g., Pparg, Ppara, Cd36), as well as Il1b, known for its proinflammatory activity related to insulin response. This evidence concerns the gene SLC2A4 and hyperthyroidism.