AKT1 and cancer: The study also used network pharmacology to determine the targets of the NHDC metabolites and found they were involved in various pathways related to cancer, ovarian steroidogenesis, proteoglycans in cancer, PI3K/protein kinase B (Akt) signaling pathway, and progesterone-mediated oocyte maturation, providing new insights into the pharmacological antitumoral potential mechanisms of NHDC [91].