Hv1 regulates NADPH oxidase activity and reduces the production of ROS in an animal model of ischemia, along with the findings that Hv1 KO microglia both in vitro and in vivo demonstrate reduced protein levels of the pro-inflammatory factors iNOS and CD16 following LPS plus interferon-γ treatment or during ischemic injury, respectively [69]. The gene discussed is NOS2; the disease is ischemia.