Indeed, we observed that in the tumor where KCNA3 exerts a positive role in increasing the survival rate when it is highly expressed (SKCM and LUAD), KCNA3 mRNA expression is related to an elevated infiltration of anti-tumor immune cell sub-populations (e.g., CD8+ and CD4+ T cells, monocytes, dendritic cells), while the presence in the tumor microenvironment of M2 pro-tumorigenic macrophages was reduced. This evidence concerns the gene CD8A and neoplasm.