Other hematological indexes proved the significant rescue of Irp2 KO-induced anemia by PT–2385 treatment in terms of red blood cell count and hemoglobin level (Figure 1B,C), with one exception: mean corpuscular volume (MCV) was not reversed by PT–2385 (Figure 1D), likely because one month of treatment was not enough time to improve all phenotypes. Here, IREB2 is linked to anemia.