Other hematological indexes proved the significant rescue of Irp2 KO-induced anemia by PT–2385 treatment in terms of red blood cell count and hemoglobin level (Figure 1B,C), with one exception: mean corpuscular volume (MCV) was not reversed by PT–2385 (Figure 1D), likely because one month of treatment was not enough time to improve all phenotypes. The gene discussed is IREB2; the disease is anemia (phenotype).