In a murine model of OVA-induced asthma, treatment with vitamin D3 showed protective effects by reducing α-smooth muscle actin expression, airway inflammation, collagen deposition, goblet cell hyperplasia, as well as TGFβ/Smad signaling, and increased activation of the Nrf2/HO-1 pathway [114]. The gene discussed is NFE2L2; the disease is asthma.