SIRT1 and inflammatory bowel disease: For instance, cardamonin, a natural flavone, has been shown to alleviate inflammatory bowel disease by inhibiting NLRP3 inflammasome activation through the Nrf2/NQO1 pathway [37]; chlorogenic acid, a polyphenolic, ameliorates oxidative stress and improves endothelial function in diabetic mice via Nrf2 activation [38]; pterostilbene suppresses oxidative stress and allergic airway inflammation through AMPK/Sirt1 and Nrf2/HO-1 pathways [39].