So, since the hippocampus and heart tissues have been linked to offspring’s neuropsychological and cardiovascular disorders caused by PAE, we designed this study to investigate the possible effect of alcohol on the gene expression of two neurohormonal systems, the renin–angiotensin system (RAS) and the kallikrein–kinin system (KKS) peptide systems, in the hippocampus and heart of adult mice of both sexes. This evidence concerns the gene REN and cardiovascular disorder.