At 21 days to stop the injection of STZ, and restore normal blood insulin and glucose control through pancreas regeneration, and obtain the metabolic memory (MM) fish, whose limb regeneration was still the same as the state of acute diabetes damage, even at 30, 60, 90 days, and this affects the genetic to daughter cells [11], as well as bnormal DNA methylation was also retained, but AGEs did not accumulate and ROS induced stress signals did not increase. This evidence concerns the gene INS and diabetes mellitus.