EDNRB and staphylococcal scalded skin syndrome: Superantigens are a kind of virulence factors that are particularly important because some of them cause significant diseases in humans: etb is one of the exfoliative toxins involved in staphylococcal scalded skin syndrome (SSSS) [34]; food contamination by enterotoxins is one of the main causes of food poisoning outbreaks [68]; and tsst-1 is responsible for the toxic shock syndrome, a severe systemic disease that can lead to multi-organ failure [69].