A prodrug of an antibiotic (177, Figure 17) that, after being converted to a desnitro derivative by Mycobacterium tuberculosis deazaflavin-dependent nitroreductase (Ddn) [258], acts by raising nitric oxide levels. To treat tuberculosis with drug resistance, it is used with bedaquiline and linezolid [259]. The gene discussed is DDN; the disease is tuberculosis.