VSIR and acute myeloid leukemia: Recently, it was found that the expression of GPX1 in AML was positively correlated with MDSC, monocyte and T-cell depletion scores, and interestingly, it was also associated with immunosuppression checkpoints (TIM3/GAL-9, SIRPα, and VISTA), and these checkpoints participate in the immunosuppressive effects of MDSCs [94].