Additionally, the AD-PRSw/oAPOE remained significantly associated with greater rates of decline in the global and executive function factor scores when terms for APOE-ε4 genetic status were included as additional predictors (both p ≤ 0.03), whereas APOE-ε4 genetic status was independently associated with greater rates of cognitive decline in all cognitive factor scores (all p ≤ 0.005; see Table 4). This evidence concerns the gene APOE and Alzheimer disease.