One of the patients also had a variant in the GPIHBP1 gene (c.523G > C, p. Gly175Arg), also of uncertain clinical significance, associated with hyperlipoproteinemia type 1D (MIM # 615947) plus the variant in APOA5 already described in the carrier state for both genes, without a typical phenotype for familial chylomicronemia. This evidence concerns the gene APOA5 and Hyperlipoproteinemia type 1.