EDN1 and cancer: Next, we identified significantly enriched KEGG (Pathways in cancer and PI3K/Akt signaling pathway) and GO (GO:0000122, GO:0045944 and GO:0045893) terms, and identified eight genes (EDN1, CCND1, MYB, MYC, RUNX1, ITGA6, IL6 and FGF2 (Fig. 2B, Supplementary Fig. 2A, B).