However, in cells exposed to a variety of stimulate factors such as inflammatory cytokines (for example, interferon-γ) and ischemia, these three catalytic β-subunits are replaced by their immunosubunits β1i (LMP2/proteasome subunit beta 9, PSMB9), β2i (multicatalytic endopeptidase complex-like 1, MECL-1) and β5i (LMP7) and then forms new subtype of proteasome called the immunoproteasome [1, 2]. The gene discussed is PSMB9; the disease is ischemia.