CD4 and acute myeloid leukemia: Compared with that in the CON group, the proportion of CD4+CD25+Foxp3+ Tregs in splenic tissues (Fig. 2B) and lymphocytes of lamina propria of the colon (Fig. 2C) of mice in the AME group was significantly increased by more than 2-fold (Fig. 2D, E; P < 0.01), while the immune balance shifted toward the Th2 phenotype in the AML group (Fig. 2D, E; P < 0.01).