On the contrary, the CD68+ macrophages markedly accumulated in the stroma of tumor tissues compared with peri-tumor tissues of CRC patients (Fig. 1D (c)), indicating that ACT1 downregulation in the tumor tissues might be the key factor to promote tumorigenesis and probably ACT1 knockdown contributed to the infiltration of CD68+ macrophages in the tumors. This evidence concerns the gene CD68 and neoplasm.