Furthermore, we found that relative expression of E-cadherin in the epithelium of CRC was markedly lower in the tumor enriched CD68+ACT1low macrophages than that in the tumor-enriched CD68+ACT1high macrophages (Fig. 1G (a-b)) and conversely, the relative expression of snail was significantly higher in the tumor enriched CD68+ACT1low macrophages than that in the tumor enriched CD68+ACT1high macrophages (Fig. 1G (a) and (c)). The gene discussed is CDH1; the disease is neoplasm.