Mediation effect in the association between thicker EAT and higher risk of HF was observed with NT-proBNP (HR [95% CI], 0.95 [0.92–0.98], P = 0.011) and GLS (HR [95% CI], 1.04 [1.01–1.07], P = 0.032). This evidence concerns the gene NPPB and hydrops fetalis.