There was an established association between LHB tendinopathy and rotator cuff pathology and LHBT instability and occult Subscapularis tears in our scoping review, with EMG studies demonstrating hyperactivity of LHB in the presence of rotator cuff tears and shoulder instability, suggesting a compensation role of the LHB in pathological shoulders. The gene discussed is LHB; the disease is rotator cuff syndrome.