Higher expression of ORC6 was significantly associated with worse prognosis in DSS for patients with 17 types of cancers (e.g., ACC, LGG and PRAD), while lower expression of ORC6 was only negatively correlated with the prognosis of COAD, OV, and THYM (Supplementary Fig. 5). This evidence concerns the gene ORC6 and adrenal cortex carcinoma.