ORC6 and cancer: Our study revealed that ORC6 expression level was closely related with TMB in 10 types of cancers (e.g., LUAD, PRAD and STAD), with MSI in 11 types of cancers (e.g., PRAD, SARC and STAD), and with the expression of 5 MMR genes in a majority of cancers (e.g., HNSC, LIHC and PRAD).