We identified a positive correlation between ORC6 expression and the immune infiltration level of CD8 + T-cells in tumors of KIRC and UVM, while a statistical negative correlation between ORC6 expression and the immune infiltration level of cancer-associated fibroblasts, tumor endothelial cells, and Treg cells in certain tumors by means of multiple immune deconvolution methods. This evidence concerns the gene CD8A and cancer.