The relationships between the ORC6 expression and tumor clinical stage, prognostic significance, biological pathways, tumor mutational burden (TMB), microsatellite instability (MSI), expression level of genes related to mismatch repair (MMR), immune subtype, tumor immune cell infiltration, and immune checkpoint genes in diverse cancers (especially prostate cancer) were also investigated. The gene discussed is ORC6; the disease is prostate carcinoma.