AFP and neoplasm: The univariate Cox analysis showed that several clinical traits (age, TNM stage, CNLC stage, Tumor size Vascular invasion, Perineural invasion, albumin, AFP, CEA and CA199) and ATLS could independently predict the prognosis as independent indicators (Fig. 5C, all p < 0.05, HR > 1, ATLS: p = 0.004, HR = 6.021, 95%CI = 1.753–20.673).