AFP and neoplasm: The multivariate ROC curves showed that the average AUC value of ATLS (AUC = 0.899) was also significantly higher when compared with other clinical features and molecular traits (e.g., gender, age, TNM stage, CNLC stage, Tumor size, Hepatitis B, Lymph node invasion, Vascular invasion, Perineural invasion, albumin, AFP, CEA and CA199) (Fig. 5B).