Additionally, our findings demonstrating that CRISPR-edited knock-in of mtNPM1 led to increased protein levels of HOXA9, MEIS1 and c-Myc, associated with increased in vitro sensitivity and in vivo efficacy to treatment with MI further explains its mechanistic linkage to the presence of mtNPM1. This evidence concerns the gene MEIS1 and myocardial infarction.