Rank ordering of super-enhancers (SEs) according to their H3K27Ac peak occupancy (ROSE plot) revealed a decline in H3K27Ac mark and associated SE activities of important AML-relevant oncogenes, including HOXA9, MEIS1, MYC, MYB, BCL2, MCL1, GFI1 and SPI1 (Fig. 2B) [36, 37]. This evidence concerns the gene GFI1 and acute myeloid leukemia.