BNC2 and fetal lower urinary tract obstruction: In our recent study, we showed that CRISPR/Cas F0 mosaic mutants or Morpholino knockdown of bnc2 in zebrafish results in a distal pronephric outlet obstruction, illustrated as a ‘vesicle’, phenocopying the human anatomical LUTO phenotype (Fig. 2A-B) [15].