In the first study, by Chatterjee et al., autoantibodies to the desmosomal protein, desmoglein-2 were found in almost all human patients with ARVC and were absent in almost all healthy subjects and patients with hypertrophic cardiomyopathy or dilated cardiomyopathy (DCM)14. Here, DSG2 is linked to Arrhythmogenic right ventricular dysplasia.