When considering only the three groups of dogs with cardiac disease (ARVC Boxers, Doberman Pinschers with DCM, and MMVD dogs), both raw and normalized anti-desmoglein-2 antibody expression significantly correlated with left ventricular chamber size (measured as normalized left ventricular internal dimension in diastole, LVIDDn). Here, DSG2 is linked to familial dilated cardiomyopathy.