The top five interacting genes were selected for analysis, and the results showed that PGAP3, GRB7, STARD3, and PSMD3 had a significant positive correlations with STAT3 in TCGA cancers (Fig. 8B), such as ovarian serous cystadenocarcinoma (OV) (Fig. 8A). The gene discussed is GRB7; the disease is ovarian serous cystadenocarcinoma.