We found significantly increased mRNA expression of STAT3 in nine tumor tissues, including glioblastoma multiforme (GBM, P = 1.1 e−71), glioma (GBMLGG P = 2.9 e−195), brain lower-grade glioma (LGG P = 2.1 e−158), esophageal carcinoma (ESCA P = 3.2 e−9), stomach and esophageal carcinoma (STES P = 1.3 e−8), stomach adenocarcinoma(STAD P = 2.5 e−22), pancreatic adenocarcinoma (PAAD P = 1.1 e−29),acute myeloid leukemia (LAML P = 1.2 e−13), and cholangiocarcinoma (CHOL P = 0.03). This evidence concerns the gene STAT3 and carcinoma of esophagus.