We found significantly decreased mRNA expression of STAT3 in nine tumor tissues, including breast invasive carcinoma (BRCA P = 4.2 e−8), cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC P = 0.04), lung adenocarcinoma (LUAD P = 1.8 e−56), kidney renal papillary cell carcinoma (KIRP P = 9.3 e−14), pan-kidney (KIPAN P = 1.3 e−10), and colon adenocarcinoma (COAD P = 1.2 e−12). This evidence concerns the gene STAT3 and invasive breast carcinoma.