STAT3 and cancer: However, in HPV-negative HNSCC (HNSC-HPV-), brain lower grade glioma (LGG), lung squamous cell carcinoma (LUSC), pancreatic adenocarcinoma (PAAD), stomach adenocarcinoma (STAD), testicular germ cell tumors (TGCT), and the expression of STAT3 and cancer-associated fibroblasts showed a positive correlation (P < 0.05).