PTEN and Familial prostate cancer: Interestingly, for HomDel in prostate cancer, the genes closely flanking PTEN, such as ATAD1, RNLS and KLLN, are concurrently downregulated with the PTEN gene consistent with the large genomic deletions of chromosome 10 previously observed in prostate cancer by FISH28 (see the vertical bar in Supplementary Fig. 6).