The currently tested COVID-19 vaccine based on virosomes-RBD/3M-052 was well tolerated and no safety or tolerability concern arose from the investigations, based on the monitoring of local and systemic effects, animal behavior, clinical chemistry, hematology, and the inflammatory cytokine profile measured in the serums, nasal washes and BALs (IL-1β, IL-6, IL-8, IL-10. This evidence concerns the gene IL6 and COVID-19.