Subcutaneous transplantation of these cells into BALB/c-nu/nu mice revealed that p52-ZER6 silencing decreased the volume of the tumors formed, whereas G6PD overexpression largely restored it (Fig. 6D), suggesting that knocking down p52-ZER6 could slowdown tumor growth, most plausibly by suppressing the PPP. Here, G6PD is linked to neoplasm.