As a result, TNTs have been utilised to accommodate potent anticancer therapeutics towards their local elution.182 Kaur et al. investigated localised cancer therapy using a pre-clinical cancer model to test the anti-tumour efficacy of TNF-related apoptosis-inducing ligand (TRAIL) releasing TNTs/Ti wire implants.183 TNTs (9 μm length and 50 nm diameter) were fabricated on Ti wire implants to achieve a TRAIL loading capacity of ~12.63 μg per implant. The gene discussed is TNFSF10; the disease is neoplasm.