G6PC1 and Hyperglycemia: In the present study, using HepG2 cells under hyperglycaemia stress as a model, we show that treatment of cells with Cr3+ resulted in significant upregulation of glycolysis enzymes (GCK and PFKL) but downregulation of gluconeogenesis enzymes (G6Pase and PEPCK) (Fig. 4b, c).