The correlation between m6A modification and PI3K/Akt signaling not only is involved in non-cancer disorders such as acute liver injury [25] and hypothermia [26] but also m6A RNA modifications were found to influence PI3K/Akt signaling in most human cancers, indicating a critical role in oncogenesis and a significant prognosis biomarker [27]. This evidence concerns the gene AKT1 and cancer.