CD274 and neoplasm: Next, in the orthotopic xenografts assay, we observed that the restoration of EGR1 rescued the inhibited tumor growth (Fig. 4g–j) and angiogenesis (Fig. 4k, l) in PD-L1-silenced tumors, unambiguously demonstrating that EGR1 functions as a necessary regulator of the pro-angiogenic function of nPD-L1.