A notable example is the disease myotonic dystrophy type 1 (DM1), in which perturbed activities of RNA-binding proteins muscleblind-like (MBNL) and CUG-BP, Elav-like family (CELF) leads to a reversion to fetal alternative splicing patterns for hundreds of genes, resulting in subsequent muscle wasting (Mankodi et al, 2002; Turner & Hilton-Jones, 2010; Wang et al, 2019). Here, MBNL1 is linked to myotonic dystrophy type 1.