IFNG and familial pancreatic carcinoma: To characterise features that define pancreatic cancer cells in which FAK loss leads to upregulation of Psmb8 and MHC-I expression in response to IFNγ, we next performed RNA sequencing of all six FAK-/- cell populations and compared this with characterised gene sets that define classical and squamous molecular subtypes42 using gene set variation analysis (GSVA) (figure 8D).