We have previously shown using a murine model of skin squamous cell carcinoma that cancer cell-intrinsic deletion of FAK expression can promote an antitumour CD8 T-cell response via modulation of the effector CD8 T-cell: regulatory T-cell ratio in tumours.24 To determine whether the observed delay in FAK-/- tumour growth was also dependent on CD8 T-cells, C57BL/6 mice were treated with either isotype control or anti-CD8 T-cell-depleting antibodies and 0.5×106 FAK-wt or FAK-/- cells were implanted into the pancreas. The gene discussed is PTK2; the disease is skin squamous cell carcinoma.