Treatment of tumour organoids from surgically resected metastases from pancreatic cancer patients with TGFβ was found to shift gene expression programmes in favour of the squamous subtype.45 Similarly, expression of Gli2 can drive squamous differentiation.47 We found that treatment of FAK-wt and FAK-/- cells, the most classical-like cell clone, with TGFβ resulted in loss of FAK function with respect to regulation of Psmb8 and H2-Kb expression, while treatment with a TGFβ inhibitor could restore FAK-dependent regulation of Psmb8 and H2-Kb in the most squamous-like cell clone. Here, GLI2 is linked to pancreatic neoplasm.