Psmb8 is a key member of the immunoproteasome and is essential for maturation of the preproteasome containing Psmb9 and Psmb10, and subsequent acquisition of catalytic activity.29 30 Little is known about the immunoproteasome in the context of pancreatic cancer and whether it can contribute to the induction of antitumour T-cell responses. The gene discussed is PSMB8; the disease is familial pancreatic carcinoma.