PSMB8 and neoplasm: MHC-I preferentially binds peptides with basic or hydrophobic C-termini, suggesting that the immunoproteasome likely yields peptides with a higher affinity for binding MHC-I.19 Our data identifying an important role for Psmb8 but not Psmb9 in regulating FAK-/- tumour growth implied that an intermediate proteasome containing β1, β2 and Psmb8 may be sufficient to increase antigen diversity.