To characterise features that define pancreatic cancer cells in which FAK loss leads to upregulation of Psmb8 and MHC-I expression in response to IFNγ, we next performed RNA sequencing of all six FAK-/- cell populations and compared this with characterised gene sets that define classical and squamous molecular subtypes42 using gene set variation analysis (GSVA) (figure 8D). Here, PSMB8 is linked to familial pancreatic carcinoma.