STAT3 and pancreatic neoplasm: Further, a greater proportion of effCD8 T-cells in FAK-/-STAT3shRNA tumours were positive for expression of the receptor programmed death receptor 1 (PD-1) (figure 7G and online supplemental figure 8), which has been shown to be a marker of tumour-reactive T-cells that have encountered antigen.39 Thus, co-depletion of FAK and STAT3 promoted extensive CD8 T-cell infiltration and further restrained pancreatic tumour growth, likely via increased CD8 T-cell engagement.