However, our understanding of FAK as an immune modulator in PDAC is limited to the effects of FAK inhibitors on the tumour stroma and immune microenvironment in murine models of pancreatic cancer.14 23 Therefore, we set out to better understand how FAK regulates the antitumour immune response with particular focus on cancer cell-intrinsic mechanisms of immune evasion. The gene discussed is PTK2; the disease is familial pancreatic carcinoma.