Forward-phase array profiling of tumour cell-secreted proteins identified a number of IFNγ-induced chemokines and cytokines likely to mediate paracrine signalling with the TME, several of which were downregulated in response to FAK loss and are protumourigenic, such as interleukin-6 (IL-6),25 26 in the context of pancreatic cancer (online supplemental figure 1A). Here, PTK2 is linked to familial pancreatic carcinoma.