Among children with SAM in the Interactions of Malnutrition and Enteric Disease (MAL-ED) study, serum C-reactive protein levels were positively associated with growth hormone levels and negatively associated with IGF-1 and its principal binding protein, IGFBP-3, indicating a state of growth hormone resistance,103 which was associated with reduced height-for-age z scores. The gene discussed is GH1; the disease is nutritional deficiency disease.