On the other hand, high levels of proteolytically shed CD163 in serum may indicate a shutdown mechanism for excessive inflammatory cytokine production at the later stage of infection, as speculated by Fabriek et al. (2009) [16], while investigating the synergistic roles of CD163 with other receptor(s), such as Siglec1 and ASFV infection [18], in the process of G. parasuis infection could be a way to uncover the mediating mechanism of CD163. This evidence concerns the gene CD163 and infection.