By using PCR-DNA sequencing to analyze immunological markers (SLC11A1, CD-14, CCL2, TLR1, TLR7, TLR8, TLR9, β defensin, SP110, SPP1, BP1, A2M, ADORA3, CARD15, IRF3, and SCART1), it was possible to identify an association between pneumonia resistance/susceptibility and nucleotide sequence differences in Baladi goats. This evidence concerns the gene SPP1 and pneumonia.