Real-time PCR was conducted to quantify the expression levels of immunological markers (SLC11A1, CD-14, CCL2, TLR1, TLR7, TLR8, TLR9, β defensin, SP110, SPP1, BP1, A2M, ADORA3, CARD15, IRF3, and SCART1) in Baladi goats with and without pneumonia resistance. This evidence concerns the gene IRF3 and pneumonia.