In this study, SLC11A1, CD-14, CCL2, TLR1, TLR7, TLR8, TLR9, β defensin, SP110, SPP1, BP1, A2M, ADORA3, CARD15, IRF3, and SCART1 were molecularly characterized in pneumonia-free and pneumonia-affected Baladi goats. Here, SPP1 is linked to susceptibility to pneumonia measurement.