We think that this is the first investigation to find nucleotide sequence variants in immune system genes (SLC11A1, CD-14, CCL2, TLR1, TLR7, TLR8, TLR9, β defensin, SP110, SPP1, BP1, A2M, ADORA3, CARD15, IRF3, and SCART1) as potential candidates for pneumonia resistance/susceptibility in Baladi goats. The gene discussed is SPP1; the disease is susceptibility to pneumonia measurement.