TGM2 and Alzheimer disease: In SH-SY5Y neuroblastoma AD model cells with glucose-induced amyloidogenesis, the destruction of the AIP-AhR complex leads to the expression of type 2 transglutaminase (TGM2) and the formation of MAM; TGM2 promotes an increase in mitochondrial Ca2+ inflow from the ER, which is accompanied by an increase in expression of amyloid precursor protein (APP) and β-secretase-1 (BACE1), an increase in Aβ, and subsequent degradation of neurons.