Ho et al. [48] reported that 12 weeks of aerobic exercise in participants with obesity aged 40–66 years at an intensity of 60% HRR for 30 min was more effective in lowering serum TNF-α levels than 12 weeks of resistance training in four sets of 8–12 repetitions. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.