Previous studies have shown an increased expression of phosphorylatedJNK (pJNK) in human postmortem brain samples from AD patients anda positive co-localization with Aβ.12 Furthermore, it has also been described in vitro that Aβ peptides are able to induce JNK activation.13−15 Therefore, it might be possible that Aβ-induced activationof JNK16 could result in neuroinflammationand contribute to neurodegeneration in AD. Here, MAPK8 is linked to Alzheimer disease.