JNK3 induction was performed at 6 months of age, i.e., whenmice still lack cognitive deficiencies and/or senile plaques, andbehavioral studies were performed at 9 months of age when mice stillshould not show behavioral impairment.37 Very interestingly, we found that JNK3 overexpression was associatedwith a behavioral impairment, not only in Tg2576 but also in WT mice.These data suggest that JNK3 induction is enough to induce alterationsin cognitive function. The gene discussed is MAPK10; the disease is Senile plaques.