SMARCA4 and pancreatic ductal adenocarcinoma: Reexpression of Brg1 in Brg1-null pancreatic ductal carcinoma cells induced epithelial-to-mesenchymal transition characterized by expression of αSMA, vimentin, loss of the epithelial marker E-Cadherin, and a change in morphology to a more elongated, spindle-shaped form (20).