Notably, inhibiting STING in addition to POLQ in KPC-Brca2–/– partially rescued the tumor size compared with the shCtrl and shSTING groups (shPOLQ + shSTING 77.1% ± 5.35% of shCtrl, P < 0.05) (Figure 6E and Supplemental Figure 6, A–C). Here, BRCA2 is linked to neoplasm.