While CXCL9 and CXCL10 are well known for CD8+ T cell recruitment, a recent study in mismatch repair–deficient colorectal cancer found that recruitment and activation of CD8+ T cells depended on overexpression of CCL5 and CXCL10 via activation of cGAS-STING and type I Interferon signaling by damaged DNA (53). This evidence concerns the gene CCL5 and colorectal cancer.