BRCA2 and neoplasm: KPC-Brca2–/– shPOLQ tumors grew at a significantly slower rate and were much smaller compared with the KPC-Brca2–/– shCtrl group 28 days after implantation (tumor volume 213 ± 19 mm3 versus 633 ± 38 mm3, P < 0.001), while POLQ knockdown did not affect KPC tumor size (Figure 2, G–I).