In this study, by using the combination of improved RNA IP-coupled high-throughput sequencing (iRIP-Seq), gene knockdown and overexpression, RNA-Seq, and histology of nasal mucosa tissue and NP tissue, we performed a detailed identification of MEX3B targets in nasal epithelial cells and explored their contribution to CRS pathogenesis. Here, MEX3B is linked to congenital rubella syndrome.