In this study, we verified the upregulation of mRNA and protein expression of MEX3B in nasal epithelial cells from patients with CRS as compared with epithelial cells from control participants without CRS, with a more profound increase in eosinophilic CRSwNP than in noneosinophilic CRSwNP and CRSsNP (Figure 1, C and D). This evidence concerns the gene MEX3B and chronic rhinosinusitis without nasal polyps.