We next analyzed the differential gene expression in whole blood from a STAT2-deficient patient (P10) during acute mild COVID-19 due to PCR-confirmed natural SARS-CoV-2 infection (D4 after symptom onset) or in the basal state, 5 months after infection, relative to a healthy control matched with the patient for age and sex. The gene discussed is STAT2; the disease is COVID-19.