TP53 and colorectal carcinoma: Chemotherapy is the common treatment approach for CRC, and5-fluorouracil(5-FU) remains the gold standard of first-line treatment.6 5-FU inhibits DNA synthesis and RNA processing,affecting cell proliferation and survival.6,7 Ithas been demonstrated that some RPs exert several extra-ribosomalfunctions and are critical players in the 5-FU treatment of cancercells.8,9 Specifically, 5-FU triggers nucleolar stressand consequently induces the release of some RPs from the ribosometo activate p53 by inhibiting the MDM2 pathway.