Transcriptomeanalysis of CRC cells silenced for uL3 (uL3ΔHCT 116p53–/– cells) and resistant to 5-FU revealed an increased expression ofthree specific ABC transporters, namely, ABCB1, ABCC9, and ABC11 (Figure 2a–c), whichensures higher amounts of the related transporters on the cell membrane.At the molecular level, the downregulation of uL3 is associated withABCB1 and ABCC9 positive regulations of mRNA stability (Figure 2d,e). Here, ABCG2 is linked to colorectal carcinoma.