TM6SF2 and fatty liver disease: For instance, a significant association of a variant in “patatin-like phospholipase domain-containing 3” (PNPLA3) gene on chromosome 22 leading to modifications in retinol metabolism [12]; or in “transmembrane 6 superfamily member 2” (TM6SF2) gene on chromosome 19 leading to an impaired lipid transporter, have been associated with fatty liver disease [13].