Immunohistochemical studies described aberrant PHD1 expression in diverse malignancies (Couvelard et al. 2008; Gossage et al. 2010; Andersen et al. 2011; Kaufmann et al. 2013; Bur et al. 2018) and suggested a prognostic relevance of PHD1 expression in non-small cell type lung cancers (Andersen et al. 2011), pancreatic endocrine tumors (Couvelard et al. 2008), and classical Hodgkin's lymphoma (Bur et al. 2018). This evidence concerns the gene EGLN2 and pancreatic neuroendocrine tumor.