In better words, in normal cells, P53 suppresses nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and induces apoptosis to keep the balance between cell proliferation and cell death but in cancer cells, BCL-2 downregulates the activity of P53 and demolishes mentioned balance and leads to uncontrolled proliferation [51]. This evidence concerns the gene TP53 and cancer.