Tumor metastasis and growth depend on large amounts of nutrients and oxygen for energy, and when cells cannot take up sufficient energy sources, this can leave tumor cells in an environment with a low level of oxygen and nutrients, a situation that promotes the production of hypoxia-inducible factors (HIF-1α) and vascular endothelial growth factor (VEGF), among others, to provide a pathway for tumor cells to obtain blood through induced angiogenesis, providing sufficient nutrients and oxygen to continue their growth [5]. This evidence concerns the gene HIF1A and neoplasm.